Лаборатория биологически свободного окисления
Отдел биоэнергетики

Руководитель: Антоненко Юрий Николаевич

Статьи

• Rokitskaya Tatyana I., Khailova Ljudmila S., Strelnik Anna G., Kotova Elena A., Mironov Vladimir F., Tatarinov Dmitry A., Antonenko Yuri N.(2025) Replacement of phenyl substituents at phosphorus by hexyl ones in 2-(2-hydroxyaryl)vinylphosphonium salts can tune the nature of the induced proton transport through lipid membranes. Biochimica et Biophysica Acta - Biomembranes, >>
• Kirsanov Roman S., Khailova Ljudmila S., Krasnov Vladimir S., Firsov Alexander M., Lyamzaev Konstantin G., Panteleeva Alisa A., Popova Lyudmila B., Nazarov Pavel A., Tashlitsky Vadim N., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2024) Spontaneous reversal of small molecule-induced mitochondrial uncoupling: the case of anilinothiophenes. FEBS Journal, >>
• Khailova Ljudmila S., Kirsanov Roman S., Rokitskaya Tatyana I., Krasnov Vladimir S., Korshunova Galina A., Kotova Elena A., Yuri N.Antonenko(2024) Mitochondrial uncoupling caused by a wide variety of protonophores is differently sensitive to carboxyatractyloside in rat heart and liver mitochondria. Biochimica et Biophysica Acta - Bioenergetics, >>
• Antonenko YN, Veselov IM, Rokitskaya TI, Vinogradova DV, Khailova LS, Kotova EA, Maltsev AV, Bachurin SO, Shevtsova EF(2024) Neuroprotective thiourea derivative uncouples mitochondria and exerts weak protonophoric action on lipid membranes. Chemico-Biological Interactions, >>
• Назаров П.А., Зиновкина Л.А., Брезгунова А.А., Лямзаев К.Г., Головин А.В., Каракозова М.В., Котова Е.А., Плотников Е.Ю., Зиновкин Р.А., Скулачев М.В., Антоненко Ю.Н.(2024) Соотношение цитотоксического и антимикробного действия коньюгатов трифенилфосфония с различными производными хинона. Биохимия, >>
• Nazarov P.A., Maximov V.S., Firsov A.M., Karakozova M.V., Panfilova V., Kotova E.A., Skulachev M.V., Antonenko Y.N.(2024) Rhodamine 19 Alkyl Esters as Effective Antibacterial Agents. International Journal of Molecular Sciences, >>
• Nazarov Pavel A., Zinovkina Lyudmila A., Brezgunova Anna A., Lyamzaev Konstantin G., Golovin Andrei V., Karakozova Marina V., Kotova Elena A., Plotnikov Egor Yu, Zinovkin Roman A., Skulachev Maxim V., Yuri N.Antonenko(2024) Relationship of Cytotoxic and Antimicrobial Effects of Triphenylphosphonium Conjugates with Various Quinone Derivatives. Biochemistry (Moscow), >>
• Kirsanov Roman S., Khailova Ljudmila S., Rokitskaya Tatyana I., Lyamzaev Konstantin G., Panteleeva Alisa A., Nazarov Pavel A., Firsov Alexander M., Iaubasarova Iliuza R., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2024) Synthesis of Triphenylphosphonium-Linked Derivative of 3,5-Ditert-butyl-4-hydroxybenzylidene-malononitrile (SF6847) via Knoevenagel Reaction Yields an Effective Mitochondria-Targeted Protonophoric Uncoupler. ACS Omega, >>
• Rokitskaya Tatyana, Kirsanov Roman S., Khailova Ljudmila S., Panteleeva Alisa A., Lyamzaev Konstantin G., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2024) Methylation of Phenyl Rings in Ester‐Stabilized Phosphorus Ylides Vastly Enhances Their Protonophoric Activity. Chembiochem : a European journal of chemical biology, >>
• Luponosov Yu N., Solodukhin A.N., Aseyev N.A., Rokitskaya T.I., Kolotova D.E., Kotova E.A., Kurkin T.S., Poletavkina L.A., Isaeva Yu A., Antonenko Yu N., Balaban P.M., Ponomarenko S.A.(2024) Nanoparticles of Push–Pull Triphenylamine-Based Molecules for Light-Controlled Stimulation of Neuronal Activity. ACS BIOMATERIALS SCIENCE & ENGINEERING, >>
• Рокицкая Т.И., Алексеев А.А., Цыбров Ф.М., Бухалович С.М., Антоненко Ю.Н., Горделий В.И.(2023) Ретиналь-содержащая анионная помпа из цианобактерии Tolypothrix campylonemoides. Биохимия, >>
• Rokitskaya Tatyana I., Alekseev Aleksey A., Tsybrov Fedor M., Bukhalovich Sergej M., Antonenko Yuri N., Gordeliy Valentin I.(2023) Retinal-Based Anion Pump from the Cyanobacterium Tolypothrix campylonemoides. Biochemistry (Moscow), >>
• Khailova Ljudmila S., Krasnov Vladimir S., Kirsanov Roman S., Popova Lyudmila B., Tashlitsky Vadim N., Kotova Elena A., Antonenko Yuri N.(2023) The transient character of mitochondrial uncoupling by the popular fungicide fluazinam is specific for liver. Archives of Biochemistry and Biophysics, >>
• Rokitskaya Tatyana I., Khailova Ljudmila S., Korshunova Galina A., Antonenko Yuri N.(2023) Efficiency of mitochondrial uncoupling by modified butyltriphenylphosphonium cations and fatty acids correlates with lipophilicity of cations: Protonophoric vs leakage mechanisms. Biochimica et Biophysica Acta - Biomembranes, >>
• Rokitskaya Tatyana I., Firsov Alexander M., Khailova Ljudmila S., Kotova Elena A., Yuri N.Antonenko(2023) Selectivity of cation transport across lipid membranes by the antibiotic salinomycin. Biochimica et Biophysica Acta - Biomembranes, >>
• Okhrimenko Ivan S., Kovalev Kirill, Petrovskaya Lada E., Ilyinsky Nikolay S., Alekseev Alexey A., Marin Egor, Rokitskaya Tatyana I., Antonenko Yuri N., Siletsky Sergey A., Popov Petr A., Zagryadskaya Yuliya A., Soloviov Dmytro V., Chizhov Igor V., Zabelsk(2023) Mirror proteorhodopsins. Communications Chemistry, >>
• Zorova Ljubava D., Pevzner Irina B., Khailova Ljudmila S., Korshunova Galina A., Kovaleva Marina A., Kovalev Leonid I., Serebryakova Marina V., Silachev Denis N., Sudakov Roman V., Zorov Savva D., Rokitskaya Tatyana I., Popkov Vasily A., Plotnikov Egor Y.(2023) Mitochondrial ATP Synthase and Mild Uncoupling by Butyl Ester of Rhodamine 19, C4R1. ANTIOXIDANTS, >>
• Novoderezhkin Vladimir I., Rokitskaya Tatyana I., Kotova Elena A., Antonenko Yuri N.(2023) Synchronization of opening and closing of two gramicidin A channels pulled together by a linker: possible relevance to channel clustering. Physical Chemistry Chemical Physics, >>
• Kirsanov Roman S., Khailova Ljudmila S., Rokitskaya Tatyana I., Iaubasarova Iliuza R., Nazarov Pavel A., Panteleeva Alisa A., Lyamzaev Konstantin G., Popova Lyudmila B., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2023) Ester-stabilized phosphorus ylides as protonophores on bilayer lipid membranes, mitochondria and chloroplasts. Bioelectrochemistry, >>
• Firsov Alexander M., Pfeffermann Juergen, Benditkis Anton S., Rokitskaya Tatyana I., Kozlov Anton S., Kotova Elena A., Krasnovsky Alexander A., Pohl Peter, Antonenko Yuri N.(2023) Photodynamic activity rather than drilling causes membrane damage by a light-powered molecular nanomotor. Journal of Photochemistry and Photobiology B: Biology, >>
• Rokitskaya T.I., Arutyunyan A.M., Khailova Ljudmila S., Kataeva Alisa D., Firsov Alexander M., Kotova Elena A., Antonenko Yuri N.(2022) Usnic Acid-Mediated Exchange of Protons for Divalent Metal Cations across Lipid Membranes: Relevance to Mitochondrial Uncoupling. International Journal of Molecular Sciences, >>
• Firsov Alexander M., Khailova Ljudmila S., Rokitskaya Tatyana I., Kotova Elena A., Antonenko Yuri N.(2022) Antibiotic Pyrrolomycin as an Efficient Mitochondrial Uncoupler. Biochemistry (Moscow), >>
• Фирсов А.М., Хайлова Л.С., Рокицкая Т.И., Котова Е.А., Антоненко Ю.Н.(2022) Антибиотик пирроломицин является эффективным разобщителем митохондрий. Biochemistry (Moscow), >>
• Krasnov Vladimir S., Kirsanov Roman S., Khailova Ljudmila S., Popova Lyudmila B., Lyamzaev Konstantin G., Firsov Alexander M., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2022) Alkyl esters of 7-hydroxycoumarin-3-carboxylic acid as potent tissue-specific uncouplers of oxidative phosphorylation: Involvement of ATP/ADP translocase in mitochondrial uncoupling. Archives of Biochemistry and Biophysics, >>
• Grivennikova Vera G., Khailova Ljudmila S., Zharova Tatyana V., Kotova Elena A., Antonenko Yuri N.(2022) Inhibition of respiratory complex I by 6-ketocholestanol: Relevance to recoupling action in mitochondria. Biochimica et Biophysica Acta - Bioenergetics, >>
• Котова Е.А., Антоненко Ю.Н.(2022) 50 лет изучения протонофоров: разобщение митохондрий как основа терапевтического действия. Acta Naturae (русскоязычная версия), >>
• Chertkova Rita V., Firsov Alexander M., Brazhe Nadezda A., Nikelshparg Evelina I., Bochkova Zhanna V., Bryantseva Tatyana V., Semenova Marina A., Baizhumanov Adil A., Kotova Elena A., Kirpichnikov Mikhail P., Maksimov Georgy V., Antonenko Yuriy N., Dolgik(2022) Multiple Mutations in the Non-Ordered Red Ω-Loop Enhance the Membrane-Permeabilizing and Peroxidase-like Activity of Cytochrome c. Biomolecules, >>
• Kotova E.A., Antonenko Y.N.(2022) Fifty Years of Research on Protonophores: Mitochondrial Uncoupling As a Basis for Therapeutic Action. Acta Naturae (англоязычная версия), >>
• Rokitskaya Tatyana I., Maliar Nina L., Siletsky Sergey A., Gordeliy Valentin I., Antonenko Yuri N.(2022) Electrophysiological Characterization of Microbial Rhodopsins Transport Properties: Electrometric and ΔpH Measurements using Planar Lipid Bilayer, Collodion Film and Fluorescent Probes Approaches. Methods in molecular biology (Clifton, N.J.), >>
• Firsov Alexander M., Franco Marcia S.F., Chistyakov Dmitry V., Goriainov S.V., Sergeeva Marina G., Kotova Elena A., Fomich M.A., Bekish A.V., Sharko O.L., Shmanai V.V., Itri R., Baptista Mauricio S., Antonenko Yuri N., Shchepinov Mikhail S.(2022) Deuterated polyunsaturated fatty acids inhibit photoirradiation-induced lipid peroxidation in lipid bilayers. Journal of Photochemistry and Photobiology B: Biology, >>
• Antonenko Yuri N., Jędrzejczyk M., Rokitskaya Tatyana I., Khailova Ljudmila S., Kotova Elena A., Huczyński A.(2022) Rate of translocation across lipid bilayer of triphenylphosphonium-linked salinomycin derivatives contributes significantly to their K+/H+ exchange activity on membranes. Bioelectrochemistry, >>
• Krasnov Vladimir S., Kirsanov Roman S., Khailova Ljudmila S., Firsov Alexander M., Nazarov Pavel A., Tashlitsky Vadim N., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2022) Alkyl esters of umbelliferone-4-acetic acid as protonophores in bilayer lipid membranes and ALDH2-dependent soft uncouplers in rat liver mitochondria. Bioelectrochemistry, >>
• Rokitskaya Tatyana I., Aleksandrova Ekaterina V., Korshunova Galina A., Khailova Ljudmila S., Tashlitsky Vadim N., Luzhkov Victor B., Antonenko Yuri N.(2022) Membrane Permeability of Modified Butyltriphenylphosphonium Cations. Journal of Physical Chemistry B, >>
• Kondrashov Oleg V., Rokitskaya Tatyana I., Batishchev Oleg V., Kotova Elena A., Antonenko Yuri N., Akimov Sergey A.(2021) Peptide-induced membrane elastic deformations decelerate gramicidin dimer-monomer equilibration. Biophysical Journal, >>
• Kharechkina Ekaterina S., Nikiforova Anna B., Belosludtsev Konstantin N., Rokitskaya Tatyana I., Antonenko Yuri N., Kruglov Alexey G.(2021) Pioglitazone Is a Mild Carrier-Dependent Uncoupler of Oxidative Phosphorylation and a Modulator of Mitochondrial Permeability Transition. Pharmaceuticals, >>
• Žuna Kristina, Jovanovic Olga, Khailova Ljudmila S., Škulj Sanja, Brkljaˇca Zlatko, Jürgen Kreiter, Kotova Elena A., Vazdar Mario, Antonenko Yuri N., Pohl Elena E.(2021) Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes. Biomolecules, >>
• Terekhova Natalia V., Khailova Lyudmila S., Rokitskaya Tatyana I., Nazarov Pavel A., Islamov Daut R., Usachev Konstantin S., Tatarinov Dmitry A., Mironov Vladimir F., Kotova Elena A., Antonenko Yuri N.(2021) Trialkyl(vinyl)phosphonium Chlorophenol Derivatives as Potent Mitochondrial Uncouplers and Antibacterial Agents. ACS Omega, >>
• Rokitskaya Tatyana I., Kotova Elena A., Antonenko Yuri N.(2021) Anomalous potentials on bilayer lipid membranes in the presence of usnic acid: Markin-Sokolov versus Nernst-Donnan equilibrium. Bioelectrochemistry, >>
• Pavlova Julia A., Khairullina Zimfira Z., Tereshchenkov Andrey G., Nazarov Pavel A., Lukianov Dmitrii A., Volynkina Inna A., Skvortsov Dmitry A., Makarov Gennady I., Abad Etna, Murayama Somay Y., Kajiwara Susumu, Paleskava Alena, Konevega Andrey L., Anton(2021) Triphenilphosphonium Analogs of Chloramphenicol as Dual-Acting Antimicrobial and Antiproliferating Agents. Antibiotics, >>
• Рокицкая Т.И., Маляр Н., Ковалев К.В., Волков А.А., Горделий В.И., Антоненко Ю.Н.(2021) КАНАЛЬНАЯ АКТИВНОСТЬ РОДОПСИНОВ МОЖЕТ БЫТЬ ВЫЯВЛЕНА ПРИ ИЗМЕРЕНИИ ПОТЕНЦИАЛЗАВИСИМОСТИ ФОТОТОКОВ НА ПЛОСКИХ БИСЛОЙНЫХ ЛИПИДНЫХ МЕМБРАНАХ. Биохимия, >>
• Rokitskaya Tatyana I., Maliar Nina, Kovalev Kirill V., Volkov Oleksandr, Gordeliy Valentin I., Antonenko Yuri N.(2021) Rhodopsin Channel Activity Can Be Evaluated by Measuring the Photocurrent Voltage Dependence in Planar Bilayer Lipid Membranes. Biochemistry (Moscow), >>
• Chertkova Rita V., Firsov Alexander M., Kotova Elena A., Gusev Ivan D., Dolgikh Dmitry A., Kirpichnikov Mikhail P., Antonenko Yuri N.(2021) Lysine 72 substitutions differently affect lipid membrane permeabilizing and proapoptotic activities of horse heart cytochrome. Biochemical and Biophysical Research Communications, >>
• Firsov Alexander M., Franco Marcia S.F., Kotova Elena A., Fomich Maksim A., Bekish Andrei V., Sharko Olga L., Shmanai Vadim V., Baptista Mauricio S., Antonenko Yuri N., Shchepinov Mikhail S.(2021) Deuterated PUFA Inhibit Oxidative Damage to Liposomes Upon Photodynamic Treatment. Biophysical Journal, >>
• Rokitskaya Tatyana I., Kotova Elena A., Luzhkov Victor B., Kirsanov Roman S., Aleksandrova Ekaterina V., Korshunova Galina A., Tashlitsky Vadim N., Antonenko Yuri N.(2021) Lipophilic ion aromaticity is not important for permeability across lipid membranes. Biochimica et Biophysica Acta - Biomembranes, >>
• Firsov Alexander M., Popova Ludmila B., Khailova Ljudmila S., Nazarov Pavel A., Kotova Elena A., Antonenko Yuri N.(2021) Protonophoric action of BAM15 on planar bilayers, liposomes, mitochondria, bacteria and neurons. Bioelectrochemistry, >>
• Antonenko Yuri N., Lapashina Anna S., Kotova Elena A., Ramonova Alla A., Moisenovich Mikhail M., Agapov Igor I.(2017) Application of Peak Intensity Analysis to Measurements of Protein Binding to Lipid Vesicles and Erythrocytes Using Fluorescence Correlation Spectroscopy: Dependence on Particle SizeJ Membrane Biology. Journal of Membrane Biology, >>
• Chelombitko Maria A., Firsov Alexander M., Kotova Elena A., Rokitskaya Tatyana I., Khailova Ljudmila S., Popova Lyudmila B., Chernyak Boris V., Antonenko Yuri N.(2020) Usnic acid as calcium ionophore and mast cells stimulator. Biochimica et Biophysica Acta - Biomembranes, >>
• Firsov Alexander M., Khailova Ljudmila S., Nazarov Pavel A., Ukraintsev Maxim, Kirsanov Roman S., Kovalchuk Sergei I., Lyamzaev Konstantin G., Panteleeva Alisa A., Korshunova Galina A., Kotova Elena A., Antonenko Yuri N.(2025) 2-Azido-4-nitrophenol is a light-sensitive antibacterial protonophore. Bioelectrochemistry, >>
• Antonenko Yuri N., Rudenko Alexander Y., Khailova Ljudmila S., Firsov Alexander M., Kirsanov Roman S., Lyamzaev Konstantin G., Panteleeva Alisa A., Popova Lyudmila B., Mariasina Sofia S., Kotova Elena A., Polshakov Vladimir I.(2025) Cyazofamid-dessulfonamide (CCIM) is an anionic uncoupler of oxidative phosphorylation in mitochondria and a protonophore on lipid membranes. Biochemical and Biophysical Research Communications, >>
• Bukhdruker Sergey, Gushchin Ivan, Shevchenko Vitaly, Kovalev Kirill, Polovinkin Vitaly, Tsybrov Fedor, Astashkin Roman, Alekseev Alexey, Mikhaylov Anatoly, Bukhalovich Siarhei, Bratanov Dmitry, Ryzhykau Yury, Kuklina Daria, Caramello Nicolas, Rokitskaya T(2025) Proteorhodopsin insights into the molecular mechanism of vectorial proton transport. Science Advances, >>
• Tereshchenkov Andrey G., Khairullina Zimfira Z., Volynkina Inna A., Lukianov Dmitrii A., Nazarov Pavel A., Pavlova Julia A., Tashlitsky Vadim N., Razumova Elizaveta A., Ipatova Daria A., Timchenko Yury V., Senko Dmitry A., Efremenkova Olga V., Paleskava A(2024) Triphenylphosphonium Analogs of Short Peptide Related to Bactenecin 7 and Oncocin 112 as Antimicrobial Agents. Pharmaceutics, >>
• Pavlova J.A., Tereshchenkov A.G., Nazarov P.A., Lukianov D.A., Skvortsov D.A., Polshakov V.I., Vasilieva B.F., Efremenkova O.V., Kaiumov M.Y., Paleskava A., Konevega A.L., Dontsova O.A., Osterman I.A., Bogdanov A.A., Sumbatyan N.V.(2023) Conjugates of Chloramphenicol Amine and Berberine as Antimicrobial Agents. Antibiotics, >>
• Saifutdinov RA, Degtyarev MI, Korobushkin DI, Artemieva SM, Byzov PS, Danilova MA, Ditts AA, Ermokhina KA, Garibian PG, Gorbunova AY, Guseva PA, Karlik EI, Kondratieva TY, Kupriyanov DA, Lebedev IM, Lebedeva NV, Nazarov PA, Neplyukhina AA, Noskova EA, Obo(2025) Taxonomic diversity and abundance of enchytraeids (Annelida, Clitellata, Enchytraeida) in the Northern Palaearctic. 2. European Russia. Biodiversity Data Journal, >>
• Karakozova MV, Sorochkina AI, Nazarov PA(2025) Two-faced Janus SkQ1/SkQR1: patterns and molecular volume threshold for substrate recognition by the AcrAB-TolC pump. Frontiers in pharmacology, >>
• Eshboev F., Mamadalieva N., Nazarov P.A., Hussain H., Katanaev V., Egamberdieva D., Azimova S.(2024) Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms. Antibiotics, >>
• Eshboev Farkhod, Karakozova Marina, Abdurakhmanov Jaloliddin, Bobakulov Khayrulla, Dolimov Khayotjon, Abdurashidov Akhror, Baymirzaev Asadali, Makhnyov Artyom, Terenteva Ekaterina, Sasmakov Sobirdjan, Piyakina Galina, Egamberdieva Dilfuza, Nazarov Pavel A(2023) Antimicrobial and Cytotoxic Activities of the Secondary Metabolites of Endophytic Fungi Isolated from the Medicinal Plant Hyssopus officinalis. Antibiotics, >>
• Nazarov PA, Majorov KB, Apt AS, Skulachev MV(2023) Penetration of Triphenylphosphonium Derivatives through the Cell Envelope of Bacteria of Mycobacteriales Order. Pharmaceuticals, >>
• Nazarov Pavel A., Khrulnova Svetlana A., Kessenikh Andrew G., Novoyatlova Uliana S., Kuznetsova Svetlana B., Bazhenov Sergey V., Sorochkina Alexandra I., Karakozova Marina V., Manukhov Ilya V.(2023) Observation of Cytotoxicity of Phosphonium Derivatives Is Explained: Metabolism Inhibition and Adhesion Alteration. Antibiotics, >>
• Nazarov P.A., Kuznetsova A.M., Karakozova M.V.(2022) Multidrug resistance pumps as a keystone of bacterial resistance. Moscow University biological sciences bulletin, >>
• Назаров П.А., Кузнецова А.M., Каракозова М.В.(2022) Помпы множественной лекарственной устойчивости как краеугольный камень резистентности бактерий. Вестник Московского университета. Серия 16: Биология, >>
• Nazarov Pavel A.(2022) MDR Pumps as Crossroads of Resistance: Antibiotics and Bacteriophages. Antibiotics, >>
• Sokolov Svyatoslav S., Smirnova Ekaterina A., Rokitskaya Tatyana I., Severin Fedor F.(2024) The Imidazolium Ionic Liquids Toxicity is Due to Their Effect on the Plasma Membrane. Biochemistry (Moscow), >>
• Oleynikov I.P., Firsov A.M., Azarkina N.V., Vygodina T.V.(2025) Cholesterol Attenuates the Pore-Forming Capacity of CARC-Containing Amphipathic Peptides. International Journal of Molecular Sciences, >>

Сотрудники

• Антоненко Юрий Николаевич
• Назаров Павел Александрович
• Рокицкая Татьяна Ивановна
• Фирсов Александр Михайлович